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Antigenic Specificity | SETDB1 - N-terminal region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | cow, dog, guinea pig, horse, human, rabbit, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against SETDB1. It was validated on Western BlotTarget Description: SETDB1 is a histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETDB1 |
Other Names | [Histone-lysine N-methyltransferase SETDB1; Histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase SETDB1; SET domain bifurcated histone lysine methyltransferase 1; ERG-associated protein with SET domain; ESET; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1] |
Gene, Accession # | [SETDB1], Gene ID: 9869, NCBI: Q15047.1, UniProt: Q15047 |
Catalog # | MBS3204388 |
Price | $335 |
Order / More Info | SETDB1 - N-terminal region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |