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Antigenic Specificity | Caspase-9 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | IgG |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues. Caspase-9 belongs to a family of caspases, cysteine-aspartic proteases involved in apoptosis and cytokine signalling. Regulation of Caspase-9 occurs through phosphorylation by an allosteric inhibitor, inhibiting dimerization and inducing a conformational change. Correct caspase-9 function is required for apoptosis, leading to the normal development of the central nervous system. Without correct function, abnormal tissue development can occur leading to abnormal function, diseases and premature death. Different protein isoforms of caspase-9 are produced due to alternative splicing. |
Immunogen | Source Note: This monoclonal antibody is produced by immunizing animals with a polypeptide corresponding to Caspase-9 protein. |
Other Names | [Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6; MCH6], [CASP9; CASP9; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; MCH6; CASP-9; APAF-3; ICE-LAP6] |
Gene, Accession # | [CASP-9], Gene ID: 842, NCBI: NP_001220.2, UniProt: P55211 |
Catalog # | MBS435301 |
Price | $350, $565 |
Order / More Info | Caspase-9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |