Edit |   |
---|---|
Antigenic Specificity | TMEM59 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide near amino terminus of human TMEM59. |
Other Names | [Transmembrane protein 59, thymic dendritic cell-derived factor 1, liver membrane bround protein, LMBP] |
Gene, Accession # | [TMEM59], Gene ID: 9528, NCBI: NP_004863 |
Catalog # | MBS9401013 |
Price | $320 |
Order / More Info | TMEM59 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |