MUNC-18 (pSer515) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | MUNC-18 (pSer515) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | bovine (expected from sequence), chicken (expected from sequence), dog (expected from sequence), human (expected from sequence), mouse (expected from sequence), primate (expected from sequence), Xenopus (expected from sequence) |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB)* |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This item recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C.. . Munc-18 is also involved in the onset of female puberty through its re |
| Immunogen | Immunogen: Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18. Buffer Solution: 10mM Hepes pH7.5 Antiserum Preparation: Antisera to rat Munc-18 (pSer515) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Rat |
| Other Names | [syntaxin-binding protein 1; Syntaxin-binding protein 1; syntaxin-binding protein 1; p67; protein unc-18 homolog 1; protein unc-18 homolog A; unc-18-1; unc-18A; syntaxin binding protein 1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; rbSec1], [Stxbp1; Stxbp1; Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1; Unc18a; Unc18-1; Unc-18A] |
| Gene, Accession # | [MUNC-18], Gene ID: 25558, NCBI: NP_037170.1, UniProt: P61765 |
| Catalog # | MBS221521 |
| Price | $550 |
| Order / More Info | MUNC-18 (pSer515) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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