PTEN Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPTEN
Clone2C10
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatimmunogen affinity purified
Size0.03 mL, 0.1 mL, 0.2 mL
Concentration1 mg/ml
ApplicationsImmunohistochemistry (IHC) Paraffin
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DescriptionSpecificity: PTEN protein detects endogenous levels of PTEN. PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-
ImmunogenImmunogen: Synthetic Peptide of PTEN at AA range of 320-400
Other Names[Mouse PTEN Mouse (2C10)]
Gene, Accession #[PTEN], Gene ID: 5728, NCBI: NP_000305.3, UniProt: P60484
Catalog #MBS9700538
Price$130, $220, $325
Order / More InfoPTEN Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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