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Antigenic Specificity | PTEN |
Clone | 2C10 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PTEN protein detects endogenous levels of PTEN. PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non- |
Immunogen | Immunogen: Synthetic Peptide of PTEN at AA range of 320-400 |
Other Names | [Mouse PTEN Mouse (2C10)] |
Gene, Accession # | [PTEN], Gene ID: 5728, NCBI: NP_000305.3, UniProt: P60484 |
Catalog # | MBS9700538 |
Price | $130, $220, $325 |
Order / More Info | PTEN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |