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Antigenic Specificity | PSEN2 (Presenilin-2 CTF subunit) (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, mouse, porcine, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.3 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This PSEN2(Presenilin-2 CTF subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 401-445 amino acids from the C-terminal region of human PSEN2(Presenilin-2 CTF subunit). Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. |
Immunogen | n/a |
Other Names | [Presenilin-2; PS-2; 3423-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2] |
Gene, Accession # | [PSEN2], Gene ID: 5664, NCBI: NP_000438.2, UniProt: P49810 |
Catalog # | MBS9204662 |
Price | $165, $370 |
Order / More Info | PSEN2 (Presenilin-2 CTF subunit) (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Levy-Lahad E.,et al.Science 269:973-977(1995). Rogaev E.I.,et al.Nature 376:775-778(1995). Li J.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184(1995). Levy-Lahad E.,et al.Genomics 34:198-204(1996). Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. |