Integrin alpha 5 (CD49e) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Integrin alpha 5 (CD49e) |
| Clone | [NKI-SAM-1] |
| Host Species | Mouse (Balb/c) |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: NKI-SAM-1 recognizes the 135-kDa integrin-alpha5 monocyte-specific antigen. The exact epitope is not known. NKI-SAM-1 strongly reacts with monocytes, and weakly with granulocytes, platelets and T-lymphocytes. Integrins are transmembrane glycoproteins that belong to the family of adhesion molecules. They promote interactions between cells and their environment, being both other cells or the extra- cellular matrix. Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated subunits, i.e. an alpha-subunit of 95 kDa that is conserved through the superfamily and a more variable beta subunit of 150-170 kDa. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have be |
| Immunogen | Source Note: NKI-SAM-1 is a monoclonal antibody obtained by immunization of Balb/c mice with Human monocytes isolated by centrifugal elutriation. |
| Other Names | [integrin alpha-5; Integrin alpha-5; integrin alpha-5; VLA-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; very late activation protein 5, alpha subunit; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5], [ITGA5; ITGA5; FNRA; CD49e; VLA5A; FNRA] |
| Gene, Accession # | Gene ID: 3678, NCBI: NP_002196.2, UniProt: P08648 |
| Catalog # | MBS570237 |
| Price | $415 |
| Order / More Info | Integrin alpha 5 (CD49e) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Te Velde, A., Klomp, J., Yard, B., De Vries, J. and Figdor, C. (1988). Modulation of phenotypic and functional properties of Human peripheral blood monocytes by IL-4. Journal Immunol 140, 1548-54. Ammon, C., Meyer, S.P., Schwarzfischer, L., Krause, S.W., Andreesen, R. and Kreutz, M. (2000). Comparitive analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Immunology 100, 364-9. Grassi, F., Dezutter-Dambuyant, C., McIlroy, D., Jacquet, C., Yoneda, K., Imamura, S., Boumsell, L., Schmitt, D., Autran, B., Debre, P., Hosmalin, A. (1998). Monocyte-derived dendritic cells have a phenotype comparable to that of dermal cells and display ultrastructural granules distinct from Birbeck granules. J Leukoc Biol 64, 484-493. Xiao, J., Messinger, Y., Jin, J., Myers, D., Bolen, J. and Uckun, F. (1996). Signal transduction through the b1 integrin Family surface adhesion Molecules VLA-4 and VLA-5 of Human B-cell precursors activates CD19 receptor-associated protein-tyrosine Kinases. J Biol Chem 271, 7659-64. Santoni, G., Birbarelli, P., Hong, L., Gamero, A., Djeu, J. and Piccoli, M. (1995). An a5b1-like integrin receptor mediates the binding of less pathogenic Candida species to fibronectin. J Med Microbiol 43, 360-7. Klingemann, H.G. and Dedhar, S. (1989). Distribution of integrins on Human peripheral blood mononuclear cells. Blood 74, 1348-54. |
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MYBIOSOURCE INC.
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