TNFAIP3 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | TNFAIP3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB (1, 2). It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs (3). Constitutive expression of A20 is observed in lymphoid tissues (4), but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha (3, 5), IL-1 (3, 5), phorbol esters (6), and LPS (7). Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF r |
| Immunogen | Immunogen: Recombinant protein of human TNFAIP3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2] |
| Gene, Accession # | [TNFAIP3], Gene ID: 7128, NCBI: NP_001257436.1, UniProt: P21580 |
| Catalog # | MBS8501872 |
| Price | $310 |
| Order / More Info | TNFAIP3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Beyaert, R. et al. (2000) Biochem Pharmacol 60, 1143-51. 2. Lee, E.G. et al. (2000) Science 289, 2350-4. 3. Dixit, V.M. et al. (1990) J Biol Chem 265, 2973-8. 4. Tewari, M. et al. (1995) J Immunol 154, 1699-706. 5. Jaattela, M. et al. (1996) J Immunol 156, 1166-73. 6. Laherty, C.D. et al. (1993) J Biol Chem 268, 5032-9. 7. Hu, X. et al. (1998) Blood 92, 2759-65. 8. Song, H.Y. et al. (1996) Proc Natl Acad Sci USA 93, 6721-5. 9. Heyninck, K. and Beyaert, R. (1999) FEBS Lett 442, 147-50. 10. Heyninck, K. et al. (1999) J Cell Biol 145, 1471-82. 11. Evans, P.C. et al. (2004) Biochem J 378, 727-34. 12. Lin, S.C. et al. (2008) J Mol Biol 376, 526-40. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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