DOK1 (N-term), 9-39 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DOK1 (N-term), 9-39 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This DOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1. DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| Immunogen | n/a |
| Other Names | [Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62; DOK1] |
| Gene, Accession # | [DOK1], Gene ID: 1796, NCBI: NP_001184189.1, UniProt: Q99704 |
| Catalog # | MBS9206118 |
| Price | $165, $370 |
| Order / More Info | DOK1 (N-term), 9-39 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Liang, X., et al., J. Biol. Chem. 277(16):13732-13738 (2002). Yamakawa, N., et al., EMBO J. 21(7):1684-1694 (2002). Hubert, P., et al., Eur. J. Immunogenet. 27(3):145-148 (2000). Nemorin, J.G., et al., J. Biol. Chem. 275(19):14590-14597 (2000). Nelms, K., et al., Genomics 53(2):243-245 (1998). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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