Interleukin-7 receptor alpha, IL-7Ralpha / CD127 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Interleukin-7 receptor alpha, IL-7Ralpha / CD127 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-alpha (CD127) and common-gamma chain receptor (CD132).1,2 IL7Ralphais required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency.3 The partial deficiency of IL-7R alpha results in an arrest of T-cell development, leading to typical severe combined immunodeficiency. It has the critical role of IL-7R alpha chain in the differentiation of T cells.4 |
| Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of human IL-7Ra. |
| Other Names | n/a |
| Gene, Accession # | [IL-7Ralpha / CD127] |
| Catalog # | MBS355127 |
| Price | $275 |
| Order / More Info | Interleukin-7 receptor alpha, IL-7Ralpha / CD127 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Noguchi M, Nakamura Y, Russell SM, et al. (1994). Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.. Science 262 (5141): 1877-80. 2. Kroemer RT, Richards WG (1997). Homology modeling study of the human interleukin-7 receptor complex. Protein Eng. 9 (12): 1135-42. 3. Shochat, C., Tal, N., Bandapalli, O. R., Palmi, C., Ganmore, I., Kronnie, G., Cario, G., Cazzaniga, G., Kulozik, A. E., Stanulla, M., Schrappe, M., Biondi, A., Basso, G., Bercovich, D., Muckenthaler, M. U., Izraeli, S. Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J. Exp. Med. 208: 901-908, 2011. 4. Roifman, C. M., Zhang, J., Chitayat, D., Sharfe, N. A partial deficiency of interleukin-7R-alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood 96: 2803-2807, 2000. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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