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Antigenic Specificity | ADAM17 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ADAM17 Antibody detects endogenous levels of total ADAM17. TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-alpha. Some tumors have hyperactivated EGFR due to upregulated TNF-alpha production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch in a ligand-independent manner and has been shown to play a role in the development of the Drosophila nervous system. |
Immunogen | Immunogen: A synthesized peptide derived from human ADAM17 |
Other Names | [disintegrin and metalloproteinase domain-containing protein 17 preproprotein; Disintegrin and metalloproteinase domain-containing protein 17; disintegrin and metalloproteinase domain-containing protein 17; ADAM metallopeptidase domain 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b] |
Gene, Accession # | [ADAM17], Gene ID: 6868, NCBI: NP_003174.3, UniProt: P78536 |
Catalog # | MBS4750734 |
Price | $335 |
Order / More Info | ADAM17 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |