DR5 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | DR5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B) detection. Background: TNFRSF10B(Tumor necrosis factor receptor superfamily, member 10b) is a human gene. It is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggest |
| Immunogen | Immunogen: E Coli-derived human DR5 recombinant protein (Position: K233-S440). Human DR5 shares 48.4% amino acid (aa) sequence identity with mouse DR5. |
| Other Names | [CD262 antigen; Cytotoxic TRAIL receptor 2; DR5; Dr5; Killer; KILLER; O14763; TNFRSF10B; TR10B; trail r2; trailr 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; Tumor necrosis factor receptor superfamily member 10B], [TNFRSF10B; TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2] |
| Gene, Accession # | [TNFRSF10B], Gene ID: 8795, NCBI: NP_003833.4, UniProt: O14763 |
| Catalog # | MBS178610 |
| Price | $315 |
| Order / More Info | DR5 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Finnberg, N., Klein-Szanto, A. J. P., El-Deiry, W. S.TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.J. Clin. Invest. 118: 111-123, 2008.2. Takeda, K., Kojima, Y., Ikejima, K., Harada, K., Yamashina, S., Okumura, K., Aoyama, T., Frese, S., Ikeda, H., Haynes, N. M., Cretney, E., Yagita, H., Sueyoshi, N., Sato, N., Nakanuma, Y., Smyth, M. J., Okumura, K.Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.Proc. Nat. Acad. Sci. 105: 10895-10900, 2008.3. Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., Rauch, C. T.TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.EMBO J. 16: 5386-5397, 1997. |
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