Edit |   |
---|---|
Antigenic Specificity | Human PUMA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human PUMA-a (GenBank Accession number Q9BXH1) This sequence is identical between a and b forms of the PUMA proteins. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. |
Immunogen | Immunogen Description: A synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human PUMA-a (GenBank Accession number Q9BXH1) This sequence is identical between a and b forms of the PUMA proteins. |
Other Names | [PUMA (C-Terminus) IHC-plus; BBC3; Bcl-2-binding component 3; BCL2 binding component 3; JFY-1; JFY1; PUMA; Human PUMA], [BBC3] |
Gene, Accession # | [PUMA], Gene ID: 27113, NCBI: NP_055232.1, UniProt: Q9BXH1 |
Catalog # | MBS241250 |
Price | $660 |
Order / More Info | Human PUMA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |