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Antigenic Specificity | RCC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous RCC1 protein. The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle and nuclear transport. Like other small GTPases, Ran is active in its GTP-bound form and inactive in its GDP-bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor (GEF) activity, which catalyzes the exchange of bound GDP for GTP. RCC1 (regulator of chromatin condensation 1) is the only known RanGEF. RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally. Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation |
Immunogen | Immunogen: Synthetic peptide from human protein at AA range: 301-350 |
Other Names | [Rabbit RCC1; RCC1; CHC1] |
Gene, Accession # | [RCC1], Gene ID: 1104, NCBI: P18754.1, UniProt: P18754 |
Catalog # | MBS9708148 |
Price | $130, $220, $325 |
Order / More Info | RCC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |