Edit |   |
---|---|
Antigenic Specificity | IL10 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: IL10 Antibody detects endogenous levels of total IL10. IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages (1, 2). IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1). Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 (1, 3). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFN gamma receptor, by upregulating expression of SOCS-1 (1, 3). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (4, 5). IL-10 is an important negative regulator of the immune response, which all |
Immunogen | Immunogen: Recombinant protein of human IL10 |
Other Names | [IL10; CSIF; GVHDS; IL-10; IL10A; TGIF; Interleukin-10; Cytokine synthesis inhibitory factor] |
Gene, Accession # | [IL10], Gene ID: 3586, NCBI: NP_000563.1, UniProt: P22301 |
Catalog # | MBS8516364 |
Price | $290 |
Order / More Info | IL10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |