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Antigenic Specificity | ARC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ARC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue. |
Immunogen | Immunogen: ARC antibody was raised against a 17 amino acid peptide near the amino terminus of human ARC. Buffer: ARC Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [ARC; ARC; FCM; MYP; NOP; NOP30; ARC; Nucleolar protein 3; Apoptosis repressor with CARD; Myp; nucleolar protein 3 (apoptosis repressor with CARD domain)], [NOL3; NOL3; ARC; FCM; MYP; NOP; NOP30; ARC; NOP; Myp; Nop30] |
Gene, Accession # | [NOL3], Gene ID: 8996, NCBI: NP_003937, UniProt: O60936 |
Catalog # | MBS150436 |
Price | $375 |
Order / More Info | ARC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |