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Antigenic Specificity | Human Homer protein homolog 1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. |
Immunogen | Immunogen: Recombinant human Homer protein homolog 1 protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8923 / sc-20807 / sc-15321 |
Other Names | [SYN47], [HOMER1; SYN47; Homer-1] |
Gene, Accession # | [HOMER1], Gene ID: 9456, NCBI: NP_001264006.1, UniProt: Q86YM7 |
Catalog # | MBS1490856 |
Price | $160, $235 |
Order / More Info | Human Homer protein homolog 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |