Edit |   |
---|---|
Antigenic Specificity | Apaf-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, bovine, rabbit, monkey, horse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.2 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: During apoptosis, Apaf-1 (apoptosis protease activating factor 1) binds to cytochrome c (Apaf-2), a reaction that requires dATP, and this leads to the formation of a large multimeric complex. The complex recruits pro-caspase-9, and activates caspase-9 (Apaf-3). Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf-1 is ubiquitously expressed in human tissues. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 1161 of human Apaf-1 |
Other Names | [APAF1; CED4; DKFZp781B1145; KIAA0413], [APAF1; APAF1; CED4; APAF-1; KIAA0413; APAF-1] |
Gene, Accession # | [Apaf-1], Gene ID: 317, NCBI: NP_001151.1, UniProt: O14727 |
Catalog # | MBS840415 |
Price | $305 |
Order / More Info | Apaf-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |