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Antigenic Specificity | Mouse VCAM-1 |
Clone | [MAB0804] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) - Paraffin, Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response. |
Immunogen | Immunogen: Cytokine stimulated mouse endothelial cells. Preparation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with cytokine stimulated mouse endothelial cells. The IgG1 fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). |
Other Names | [Mouse VCAM-1 (#MAB0804); CD106; Vascular Cell Adhesion Protein 1; V-CAM 1;], [Vcam1; Vcam1; CD106; Vcam-1; Vcam-1; V-CAM 1; VCAM-1] |
Gene, Accession # | [VCAM-1], Gene ID: 22329, NCBI: NP_035823.3, UniProt: P29533 |
Catalog # | MBS690530 |
Price | $490 |
Order / More Info | Mouse VCAM-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |