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Antigenic Specificity | WAVE (Tyr-150), phospho-specific [Conserved Site] |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody was cross-adsorbed to phospho-WAVE (Tyr-125) and unphosphorylated WAVE (Tyr-150) peptides before affinity purification using phospho-WAVE (Tyr-150) peptide. In western blots, the antibody detects a 78 kDa* corresponding to phosphorylated WAVE2 in K562 cells treated with pervanadate and a 80 kDa band corresponding to WAVE1 in HUVEC treated with pervanadate. It also recognizes an unidentified band near 50 kDa in K562 cells. The Wiskott-Aldrich syndrome protein (WASP) family is involved in various pathways that regulate actin cytoskeletal organization. This family includes WASP, N-WASP, and three WAVE/SCAR isoforms, WAVEs 1, 2, and 3. WAVE proteins play key roles in actin-mediated cell events, such as membrane ruffling and lamell |
Immunogen | Immunogen: Phospho-WAVE (Tyr-150) peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-150 in human WAVE2. This sequence has high homology with similar regions in rat and mouse WAVE2, and has homology to the conserved sites in WAVE1 (Tyr-151) and WAVE3 (Tyr-151). |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS472068 |
Price | $385 |
Order / More Info | WAVE (Tyr-150), phospho-specific [Conserved Site] Antibody from MYBIOSOURCE INC. |
Product Specific References | • Ardern, H. et al. (2006) Cell Motil. Cytosk. 63:6.• Leng, Y. et al. (2005) PNAS 102(4):1098.• Suetsugu, S. et al. (1999) Bioch. Biophs. Res. Comm. 260:296.• Miki, H. et al. (1999) J Biol. Chem. 274(39):27605. |