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Antigenic Specificity | LEF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumo |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [KFZp586H0919; TCF1ALPHA], [LEF1; LEF1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; LEF-1; TCF1-alpha] |
Gene, Accession # | [LEF1], Gene ID: 51176, NCBI: Q9UJU2.1, UniProt: Q9UJU2 |
Catalog # | MBS125539 |
Price | $200, $275, $430 |
Order / More Info | LEF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |