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Antigenic Specificity | DKK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Xenopus Dickkopf (Dkk)-1 was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of Dkk have been identified in mammals. Each Dkk molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of Dkk1 and Dkk2 inhibited Wnt-3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of Dkk-2, but not that of Dkk-1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 255 of mouse Dkk1 |
Other Names | [DKK-1; DKK1; SK; dickkopf homolog 1; dickkopf-1; dickkopf-1 like], [Dkk1; Dkk1; mdkk-1; Dickkopf-1; Dkk-1; mDkk-1] |
Gene, Accession # | [DKK1], Gene ID: 13380, NCBI: NP_034181.2, UniProt: O54908 |
Catalog # | MBS841192 |
Price | $150, $300 |
Order / More Info | DKK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |