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Antigenic Specificity | Human ACTA2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] |
Immunogen | Immunogen: A synthetic peptide of human ACTA2 |
Other Names | [ACTA2 Rabbit pab], [ACTA2; AAT6; ACTSA; Actin; aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein] |
Gene, Accession # | [ACTA2] |
Catalog # | MBS125358 |
Price | $200, $275, $430 |
Order / More Info | Human ACTA2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Herman, I.M. Actin isoforms. Curr. Opin. Cell Biol. 5: 48-55 (1993).2. Bailly, M., et al. The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension. Curr Biol. 11: 620-5 (2001).3. Lim, Y.P., et al. Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs. Clin. Cancer Res. 10: 3980-3987 (2004).4. Olson, T.M., et al. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 280: 750-2 (1998).5. Miwa, T., et al. Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. Mol Cell Biol. 11: 3296-306 (1991). |