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Antigenic Specificity | TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) |
Clone | [TRAF1/2770] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of Ly |
Immunogen | Immunogen: Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary) Positive Control: HeLa or 293T Cells. Hodgkins Lymphoma |
Other Names | [EBI6; EBV induced protein 6; Epstein-Barr virus-induced protein 6; TNF receptor-associated factor 1; TRAF1] |
Gene, Accession # | [TRAF1], Gene ID: 7185, NCBI: NP_001177874.1, UniProt: Q13077 |
Catalog # | MBS4380706 |
Price | $190, $340, $340 |
Order / More Info | TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Assaf C., et al. J Invest Dermatol 127(8):1898-1904, 2007 |