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Antigenic Specificity | IL12RB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: Recombinant protein of human IL12RB1 Immunogen Species: Human |
Other Names | [CD212; IL-12R-BETA1; IL12RB; IMD30] |
Gene, Accession # | [IL12RB1], Gene ID: 3594, NCBI: NP_001276952.1, UniProt: P42701 |
Catalog # | MBS9133363 |
Price | $200, $275, $430 |
Order / More Info | IL12RB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |