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Antigenic Specificity | TAK1 (Ab-184) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total TAK1 protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activ |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized non-phosphopeptide derived from human TAK1 around the phosphorylation site of threonine 184 (I-Q-T(p)-H-M). |
Other Names | [EC 2.7.11.25; M3K7; MAP3K7; Mitogen-activated protein kinase kinase kinase 7; TGF-beta-activated kinase 1] |
Gene, Accession # | [TAK1], Gene ID: 6885, NCBI: NP_003179.1, UniProt: O43318 |
Catalog # | MBS9401093 |
Price | $200, $255 |
Order / More Info | TAK1 (Ab-184) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |