HIF1 alpha Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | HIF1 alpha |
| Clone | [HIF1A-84] |
| Host Species | Mouse |
| Reactive Species | human. |
| Isotype | IgG2b, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IG), Functional Studies |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteaso |
| Immunogen | Immunogen: Recombinant human HIF1 alpha protein Quantity and Buffer: 0.5 ml at 200ug/ml with BSA and azide |
| Other Names | [ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78 (bHLHe78); Hypoxia inducible factor 1 alpha; Member of PAS superfamily 1 (MOP1); PAS domain-containing protein 8 (PASD8)], [HIF1A; HIF1A; HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; BHLHE78; MOP1; PASD8; HIF-1-alpha; HIF1-alpha; bHLHe78] |
| Gene, Accession # | [HIF1A], Gene ID: 3091, NCBI: NP_001230013.1, UniProt: Q16665 |
| Catalog # | MBS438355 |
| Price | $190, $340, $340 |
| Order / More Info | HIF1 alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Wang GL and Semenza GL. 1993. Proc. Natl. Acad. Sci. 90:4304.2. Wang GL and Semenza GL. 1993. J. Biol. Chem. 268:21513.3. Wang GL and Semenza GL. 1995. J. Biol. Chem. 270:1230.4. Galbraith MD, et al. 2013. Cell. 153:1327. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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