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Antigenic Specificity | DDX58 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Antiviral innate immunity depends on the combination of parallel pathways triggered by virus detecting proteins in the Toll-like receptor (TLR) family and RNA helicases, such as Rig-I (retinoic acid-inducible gene I) and MDA-5 (melanoma differentiation-associated antigen 5), which promote the transcription of type I interferons (IFN) and antiviral enzymes (1-3). TLRs and helicase proteins contain sites that recognize the molecular patterns of different virus types, including DNA, single-stranded RNA (ssRNA), double-stranded RNA (dsRNA), and glycoproteins. These antiviral proteins are found in different cell compartments; TLRs (i.e. TLR3, TLR7, TLR8, and TLR9) are expressed on endosomal membranes and helicases are localized to the cytoplasm. |
Immunogen | Immunogen: A synthetic peptide of human DDX58 Calculated Molecular Weight: 107kDa |
Other Names | [Rig-I: DDX58; DKFZp434J1111; DKFZp686N19181; FLJ13599; RIG-I], [DDX58; DDX58; RIGI; RIG-I; RLR-1; RLR-1; RIG-1; RIG-I] |
Gene, Accession # | [DDX58], Gene ID: 23586, NCBI: O95786.2, UniProt: O95786 |
Catalog # | MBS125909 |
Price | $200, $275, $430 |
Order / More Info | DDX58 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |