SMAD2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | SMAD2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-beta signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy-terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can t |
| Immunogen | Immunogen: Recombinant protein of human SMAD2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [SMAD2; V18; JV18-1; MADH2; MADR2; MGC22139; MGC34440; hMAD-2; hSMAD2] |
| Gene, Accession # | [SMAD2], Gene ID: 4087, NCBI: NP_001003652.1, UniProt: Q15796 |
| Catalog # | MBS8527330 |
| Price | $310 |
| Order / More Info | SMAD2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Heldin, C.H. et al. (1997) Nature 390, 465-471. 2. Attisano, L. and Wrana, J.L. (1998) Curr. Opin. Cell Biol. 10, 188-194. 3. Derynck, R. et al. (1998) Cell 95, 737-740. 4. Massague, J. (1998) Annu. Rev. Biochem. 67, 753-791. 5. Whitman, M. (1998) Genes Dev. 12, 2445-2462. 6. Wu, G. et al. (2000) Science 287, 92-97. 7. Attisano, L. and Wrana, J.L. (2002) Science 296, 1646-1647. 8. Moustakas, A. et al. (2001) J. Cell Sci. 114, 4359-4369. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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