Phospho-Cortactin (Tyr421) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Cortactin (Tyr421) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-Cortactin (Tyr421) antibody detects endogenous levels of Cortactin only when phosphorylated at Tyrosine 421. Description: Cortactin a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches.Function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CT |
| Immunogen | Immunogen: A synthesized peptide derived from human Cortactin around the phosphorylation site of Tyrosine 421 Subcellular Location: Cytoplasm > Cytoskeleton. Cell Projection > Lamellipodium. Cell projection > Ruffle. Associated with membrane ruffles and lamellipodia. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (91%), Bovine (91%), Horse (91%), Sheep (82%), Rabbit (91%), Dog (82%), Xenopus (80%) |
| Other Names | [Amplaxin; CTTN; EMS 1; EMS1; FLJ34459; Mammary tumor and squamous cell carcinoma associated; Oncogene EMS1; p80/85 src substrate; Src substrate cortactin; SRC8_HUMAN] |
| Gene, Accession # | [CTTN], Gene ID: 2017, NCBI: NP_001171669.1, UniProt: Q14247 |
| Catalog # | MBS9601205 |
| Price | $240, $280 |
| Order / More Info | Phospho-Cortactin (Tyr421) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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