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Antigenic Specificity | PCGF6 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Immunofluorescence (IF), ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This PCGF6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 261-295 amino acids from the C-terminal region of human PCGF6. Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Immunogen | n/a |
Other Names | [Polycomb group RING finger protein 6; Mel18 and Bmi1-like RING finger; RING finger protein 134; PCGF6; MBLR; RNF134] |
Gene, Accession # | [PCGF6], Gene ID: 84108, NCBI: NP_001011663.1, UniProt: Q9BYE7 |
Catalog # | MBS9203828 |
Price | $165, $370 |
Order / More Info | PCGF6 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Akasaka T.,et al.Genes Cells 7:835-850(2002). Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 429:375-381(2004). Lee M.G.,et al.Cell 128:877-887(2007). Maertens G.N.,et al.PLoS ONE 4:E6380-E6380(2009). |