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Antigenic Specificity | GFI1b |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total GFI1b protein. Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lympho |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.322~326(H-R-E-S-Q) derived from Human GFI1b. |
Other Names | [Gfi-1b] |
Gene, Accession # | [GFI1b ], Gene ID: 8328, NCBI: NP_001128503.1, UniProt: Q5VTD9 |
Catalog # | MBS9409078 |
Price | $200, $255 |
Order / More Info | GFI1b Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |