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Antigenic Specificity | PKC alpha |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Protein kinase C alpha type(PRKCA) detection. Tested with WB in Human;Mouse;Rat. Background: Protein kinase C (PKC) is the major phorbol ester receptor. Activation of PKC by calcium ions and the second messenger diacylglycerol is thought to play a central role in the induction of cellular responses to a variety of ligand-receptor systems and in the regulation of cellular responsiveness to external stimuli. Three of these, termed alpha, beta and gamma, are highly homologous. PRKCA1 is mapped to 17q22-q23.2. PRKCA1 regulates cardiac contractility and propensity toward heart failure. |
Immunogen | Immunogen: E Coli-derived human PKC alpha recombinant protein (Position: M153-L342). Human PKC alpha shares 97% and 99% amino acid (aa) sequence identity with mouse and rat PKC alpha, respectively. Ig Type: Rabbit IgG |
Other Names | [Protein kinase C alpha type; AAG6; Aging associated gene 6; aPKC; KPCA_HUMAN; MGC129900; MGC129901; PICK 1; PKC A; PKC alpha; PKC-A; PKC-alpha; PKCA; PRKACA; PRKC A; PRKCA; Protein Kinase C alpha; Protein kinase C alpha type; protein kinase C, alpha], [PRKCA; PRKCA; AAG6; PKCA; PRKACA; PKC-alpha; PKCA; PRKACA; PKC-A; PKC-alpha] |
Gene, Accession # | [PKC alpha], Gene ID: 5578, NCBI: NP_002728.1, UniProt: P17252 |
Catalog # | MBS178350 |
Price | $315 |
Order / More Info | PKC alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Braz, J. C.; Gregory, K.; Pathak, A.; Zhao, W.; Sahin, B.; Klevitsky, R.; Kimball, T. F.; Lorenz, J. N.; Nairn, A. C.; Liggett, S. B.; Bodi, I.; Wang, S.; and 9 others : PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Med. 10: 248-254, 2004. 2. Latos-Bielenska, A.; Klett, C.; Just, W.; Hameister, H. : Refinement of localization of the human genes for myeloperoxidase (MPO), protein kinase C, alpha polypeptide, PRKCA, and the DNA fragment D17S21 on chromosome 17q. Hereditas 115: 69-72, 1991. |