HDAC1 (C19) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | HDAC1 (C19) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse, rat, and human HDAC1. HDAC1, the mammalian homologue of the yeast transcriptional regulator Rpd3p, was first purified using a trapoxin affinity matrix (1). Trapoxin is a cyclotetrapeptide that inhibits histone deacetylation in vivo and also correlates with an increase in the acetylation levels of all four core histones (1&2). These data support a role for HDAC1 as a key histone deacetylase. The function of HDAC1 has been further refined as responsible for the deacetylation of lysine residues on the N-terminal region of the core histones H2A, H2B, H3 and H4 (3&4). |
| Immunogen | Immunogen: Synthetic peptide mapping to the carboxy terminal domain of human HDAC1. |
| Other Names | [histone deacetylase 1; Histone deacetylase 1; histone deacetylase 1; reduced potassium dependency, yeast homolog-like 1; histone deacetylase 1], [HDAC1; HDAC1; HD1; RPD3; GON-10; RPD3L1; RPD3L1; HD1] |
| Gene, Accession # | [HDAC1], Gene ID: 3065, NCBI: NP_004955.2, UniProt: Q13547 |
| Catalog # | MBS440062 |
| Price | $240 |
| Order / More Info | HDAC1 (C19) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Taunton J, Hassig CA, Schreiber SL. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.2. Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL. 1998. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. PNAS 95(7):3519-3524.3. Lopez-Rodas G, Brosch G, Georgieva EI, Sendra R, Franco L, Loidl P. 1993. Histone deacetylase. A key enzyme for the binding of regulatory proteins to chromatin. FEBS lett 317(3):175-180.4. Johnson CA, White DA, Lavender JS, O?Neill LP, Turner BM. 2002. Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitated with ATP-dependent charperone protein Hsp-70. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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