CTSB Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CTSB |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cathepsin B (CSTB), part of the papain family of proteases, is a widely expressed lysosomal cysteine endopeptidase (1, 2). Like other family members, cathepsin B is produced from a larger precursor form, pro-cathepsin B, which in its glycosylated form runs at approximately 40 kDa on SDS-PAGE, and is then activated by cleavage of a 62-amino acid pro-peptide. High levels of cathepsin B are found in macrophages and osteoclasts, as well as various types of cancer cells, including lung, colon, prostate, breast, and stomach. In addition, expression of cathepsin B has been associated with multiple sclerosis (3), rheumatoid arthritis (4), and pancreatitis (5). While generally localized to lysosomes, in cancer alterations can lead to its secretion ( |
| Immunogen | Immunogen: Recombinant protein of human CTSB Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CTSB; APPS; CPSB; Cathepsin B] |
| Gene, Accession # | [CTSB], Gene ID: 1508, NCBI: NP_001899.1, UniProt: P07858 |
| Catalog # | MBS8501741 |
| Price | $310 |
| Order / More Info | CTSB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Chan, S.J. et al. (1986) Proc Natl Acad Sci USA 83, 7721-5. 2. Fong, D. et al. (1986) Proc Natl Acad Sci USA 83, 2909-13. 3. Bever, C.T. et al. (1994) Neurology 44, 745-8. 4. Hashimoto, Y. et al. (2001) Biochem Biophys Res Commun 283, 334-9. 5. Halangk, W. et al. (2000) J Clin Invest 106, 773-81. 6. Berquin, I.M. and Sloane, B.F. (1996) Adv Exp Med Biol 389, 281-94. 7. Yan, S. et al. (1998) Biol Chem 379, 113-23. 8. Vasiljeva, O. et al. (2006) Cancer Res 66, 5242-50. 9. Campo, E. et al. (1994) Am J Pathol 145, 301-9. 10. Foekens, J.A. et al. (1998) J Clin Oncol 16, 1013-21. 11. Werle, B. et al. (1999) Br J Cancer 81, 510-9. 12. Lah, T.T. et al. (2000) Clin Cancer Res 6, 578-84. 13. Werle, B. et al. (2000) Cancer 89, 2282-91. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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