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Antigenic Specificity | Amyloid-beta (N-term), Human |
Clone | VU17 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin/Paraffin, Immuno Assay (IA), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Antibody clone VU17, formerly known as alphaVU Abeta 17, recognizes the N-terminus of human amyloid beta (i.e. in: Abeta1-38; Abeta1-39; Abeta1-40; Abeta1-42). Amyloid beta peptides are of key importance in the development of Alzheimer's disease (AD) and are present in CSF. AD affects approximately 1% of the population over the age of 80. The disease is characterized by aggregation of Abeta into oligomers, fibrils and plaques deposition of insoluble and aggregated protein in the brain where its neurotoxic action leads to neuronal cell death. The deposits, also called amyloid plaques, are formed around the neuropil. The exact molecular mechanism is still unclear. Abeta is a proteolytic cleavage product, by APP-cleaving enzyme 1 (BACE1) and b |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS584771 |
Price | $520 |
Order / More Info | Amyloid-beta (N-term), Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Verwey, N et al; Immunohistochemical characterization of novel monoclonal antibodies against the N-terminus of amyloid beta-peptide. Amyloid 2013, 20:3 2. Verwey, N et al; Quantification of amyloid beta 40 in cerebrospinal fluid. Journal of Immunology methods 2009, 348:1-2 |