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Antigenic Specificity | Sin3B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Sin3B antibody detects endogenous levels of total Sin3B. Function: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.Subunit Structure: Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6or |
Immunogen | Immunogen: A synthesized peptide derived from human Sin3B Subcellular Location: Nuclear |
Other Names | [Histone deacetylase complex subunit Sin3b; Paired amphipathic helix protein Sin3b; SIN3 homolog B transcription regulator; SIN3 transcription regulator family member B; SIN3 transcription regulator homolog B; Transcriptional corepressor Sin3b] |
Gene, Accession # | [Sin3B], Gene ID: 23309, NCBI: NP_001284524.1, UniProt: O75182 |
Catalog # | MBS9602242 |
Price | $240, $280 |
Order / More Info | Sin3B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |