RFWD2 (C-term), 672-701 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | RFWD2 (C-term), 672-701 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This RFWD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of human RFWD2. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the ess |
| Immunogen | n/a |
| Other Names | [E3 ubiquitin-protein ligase RFWD2; 632-; Constitutive photomorphogenesis protein 1 homolog; hCOP1; RING finger and WD repeat domain protein 2; RING finger protein 200; RFWD2; COP1; RNF200] |
| Gene, Accession # | [RFWD2], Gene ID: 64326, NCBI: NP_001001740.1, UniProt: Q8NHY2 |
| Catalog # | MBS9210358 |
| Price | $165, $370 |
| Order / More Info | RFWD2 (C-term), 672-701 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Shimada, M., et al. Hum. Genet. 128(4):433-441(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Kinyo, A., et al. J. Invest. Dermatol. 130(2):541-545(2010) Li, D.Q., et al. Proc. Natl. Acad. Sci. U.S.A. 106(41):17493-17498(2009) Kato, S., et al. J. Biol. Chem. 283(51):35464-35473(2008) |
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MYBIOSOURCE INC.
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