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Antigenic Specificity | REN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total REN protein. Renin is a secreted proteinase whose enzymatic activity is to convert angiotensinogen into angiotensin I in the plasma, initiating a process that results in an elevation of blood pressure and increased sodium retention by the kidney (1). Renin is synthezed in kidney as a procursor, prorenin, which is released into circulation. Both renin and prorenin can bind to (pro)renin receptor and induce angiotensin-independent signaling events leading to activation of MAPKs and up-regulation of TGF-b1 and matrix proteins (2, 3). Defects in renin can cause renal tubular dysgenesis, a severe autosomal recessive disorder of renal tubular development (4, 5). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human REN. |
Other Names | [FLJ10761] |
Gene, Accession # | [REN], Gene ID: 5972, NCBI: NP_000528.1, UniProt: P00797 |
Catalog # | MBS9402338 |
Price | $255 |
Order / More Info | REN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |