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Antigenic Specificity | TNFAIP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorecence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB (1,2). It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs (3). Constitutive expression of A20 is observed in lymphoid tissues (4), but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha (3,5), IL-1 (3,5), phorbol esters (6), and LPS (7). Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF rece |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2], [TNFAIP3; TNFAIP3; A20; OTUD7C; TNFA1P2; OTUD7C; TNF alpha-induced protein 3] |
Gene, Accession # | [TNFAIP3], Gene ID: 7128, NCBI: P21580.1, UniProt: P21580 |
Catalog # | MBS126517 |
Price | $200, $275, $430 |
Order / More Info | TNFAIP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |