NES Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | NES |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2, 3). Perforin is a pore-forming protein that facilitates the entry of cytotoxic serine protea |
| Immunogen | Immunogen: Recombinant protein of human PRF1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [PRF1; FLH2; HPLH2; MGC65093; P1; PFN1; PFP], [PRF1; PRF1; P1; PFP; HPLH2; PFP; P1; PFP] |
| Gene, Accession # | [NES], Gene ID: 5551, NCBI: NP_001076585.1, UniProt: P14222 |
| Catalog # | MBS859018 |
| Price | $290 |
| Order / More Info | NES Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Trapani, J.A. (2001) Genome Biol. 2, REVIEWS 3014. 2. Lord, S.J. et al. (2003) Immunol. Rev. 193, 31-8. 3. Trapani, J.A. and Sutton, V.R. (2003) Curr. Opin. Immunol. 15, 533-43. 4. Catalfamo, M. and Henkart, P.A. (2003) Curr. Opin. Immunol. 15, 522-7. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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