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Antigenic Specificity | TRIB3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human TRIB3 (NP 066981.2). |
Other Names | [NIPK; SINK; TRB3; SKIP3; C20orf97] |
Gene, Accession # | [TRIB3], Gene ID: 57761, NCBI: Q96RU7.2, UniProt: Q96RU7 |
Catalog # | MBS8545580 |
Price | $280 |
Order / More Info | TRIB3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |