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Antigenic Specificity | PKM1/2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total PKM1/2 protein. Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa. 36~40(D-S-P-P-I) derived from Human PKM1/2. |
Other Names | [PKM; PK3; OIP3; PK2] |
Gene, Accession # | [PKM1/2], Gene ID: 5315, NCBI: NP_001193725.1, UniProt: P14618 |
Catalog # | MBS9404828 |
Price | $200, $255 |
Order / More Info | PKM1/2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |