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Antigenic Specificity | p130 Cas (Tyr-751), phospho-specific |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose and to phospho-p130 Cas (Tyr-762) peptide before affinity purification using phospho-p130 Cas (Tyr-751) peptide (without carrier). The antibody detects a 130 kDa* protein corresponding to the molecular mass of phosphorylated p130 Cas on SDS-PAGE immunoblots of pervanadate treated human endothelial and A431 cells, but is not observed in control cells. p130 Cas (Crk-associated substrate (CAS), breast cancer antiestrogen resistance 1 (BCAR1)) is a docking protein containing multiple protein-protein interaction domains. The amino-terminal SH3 domain may function as a molecular switch regulating CAS tyrosine phosphorylation, as it interacts with focal adhesion kinase (FAK) a |
Immunogen | Immunogen: Phospho-p130 Cas (Tyr-751) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 751 in rat p130 Cas. This rat sequence is the same as Tyr-653 in human p130 Cas and Tyr-657 in mouse p130 Cas. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS472042 |
Price | $385 |
Order / More Info | p130 Cas (Tyr-751), phospho-specific Antibody from MYBIOSOURCE INC. |
Product Specific References | • Nakamoto, T. et al. (1996) J Biol Chem. 271 (15):8959.• Pellicena, P. & Miller, W.T. (2001) J Biol Chem. 276 (30):28190.• Kim, D.H. et al. (2003) Biochem Biophys Res Comm. 300:141.• Shin, N.-Y. et al. (2004) J Biol Chem. 279 (37):38331. |