Human FOXP3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human FOXP3 |
| Clone | [236A/E7] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.025 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one |
| Immunogen | n/a |
| Other Names | [Human FOXP3; Forkhead box protein P3; FOXP3; Scurfin; Forkhead box protein P3 41 kDa form; IPEX] |
| Gene, Accession # | [FOXP3], Gene ID: 50943, NCBI: NP_001107849.1, UniProt: Q9BZS1 |
| Catalog # | MBS2553761 |
| Price | $110, $250 |
| Order / More Info | Human FOXP3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hori S, et al. 2003. Science 299:1057. 2. Gandhi R, et al. 2010. Nat. Immunol. 11:846. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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