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Antigenic Specificity | RSPO1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RSPO1 Antibody: RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular beta-catenin, thereby regulating functions mediated by beta-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to |
Immunogen | Immunogen: RSPO1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human RSPO1. Buffer: RSPO1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [RSPO1; RSPO; CRISTIN3; R-spondin-1; Roof plate-specific spondin-1; hRspo1; R-spondin homolog (Xenopus laevis)], [RSPO1; RSPO1; RSPO; CRISTIN3; hRspo1] |
Gene, Accession # | [RSPO1], Gene ID: 284654, NCBI: NP_001033722, UniProt: Q2MKA7 |
Catalog # | MBS150333 |
Price | $375 |
Order / More Info | RSPO1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |