Edit |   |
Antigenic Specificity | Akt2 (PKB beta) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, bovine, chicken, dog, guinea pig, hamster, monkey, porcine, rabbit, sheep, Xenopus |
Isotype | n/a |
Format | APC-Cy7 conjugate |
Size | 0.4 mL |
Concentration | 0.25 mg/ml |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~65 kDa. Does not react with PKBalpha (Akt1) or PKBgamma (Akt3). Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 (1-3). Myelin basic protein and histone H2B are in vitro substra |
Immunogen | Immunogen: A five residue synthetic peptide from the C-terminal of human AKT2, coupled to KLH |
Other Names | [Rabbit Human Akt2 (PKB beta); AKT2; PKB; PKB beta; PRKBB; protein kinase Akt2; RAC BETA] |
Gene, Accession # | [AKT2], Gene ID: 208, NCBI: NP_001617.1, UniProt: P31751 |
Catalog # | MBS8004205 |
Price | $475 |
Order / More Info | Akt2 (PKB beta) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Downward J. (1998). Curr Opin Cell Biol. 10(2): 262-7. 2. Brazil D.P., and Hemmings B.A. (2001). Biochem Sci. 26(11):657-64. 3. Nicholson K.M., Anderson N.G. (2002). Cell Signal. 14(5): 381-95. 4. Hardie, G., Hanks, S. (1995). The Protein Kinase Facts Book, Protein-Serine Kinases Academic Press Limited, San Diego, CA 418pps. |