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Antigenic Specificity | PIAS3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP 006090.2). |
Other Names | [ZMIZ5] |
Gene, Accession # | [PIAS3], Gene ID: 10401, NCBI: NP_006090.2, UniProt: Q9Y6X2 |
Catalog # | MBS8548991 |
Price | $280 |
Order / More Info | PIAS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |