p38 MAP Kinase (Thr-180/Tyr-182), phospho-specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | p38 MAP Kinase (Thr-180/Tyr-182), phospho-specific |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunocytochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects a 42 kDa* protein corresponding to the apparent molecular mass of p38-alpha on SDS-PAGE immunoblots of pervanadate treated human Jurkat and A431 cells, as well as anisomycin treated human HeLa cells. p38 MAP kinase (MAPK), also called RK, CSBP, and SAPK2a, is the mammalian orthologue of the yeast HOG kinase. This family of kinases participates in signaling cascades that control cellular responses to cytokines and stress. Four isoforms of p38 MAPK (alpha, beta, gamma, delta) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides, UV light and growth factors. MKK3 and SEK activate p38 MAPK by dual |
| Immunogen | Immunogen: Clone M139 was generated from a phospho-p38-alpha (Thr-180/Tyr-182) synthetic peptide (coupled to KLH) corresponding to amino acid residues around threonine 180 and tyrosine 182 of rat p38alpha. This peptide sequence is highly conserved in the p38beta, gamma, and delta MAPKs, and is identical in human and mouse p38-alpha. |
| Other Names | [p38 MAP Kinase (Thr-180/Tyr-182); phospho-specific; MAP kinase p38; CRK], [LOC100533304] |
| Gene, Accession # | Gene ID: 100533304, NCBI: NP_001191531.1 |
| Catalog # | MBS470020 |
| Price | $385 |
| Order / More Info | p38 MAP Kinase (Thr-180/Tyr-182), phospho-specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Han, J. et al. (1994) Science 265, 808-811.• Lee, J. C. et al. (1994) Nature 372, 739-746.• Rouse, J. et al. (1994) Cell 78, 1027-1037.• Freshney, N. W. et al. (1994) Cell 78, 1039-1049.• Raingeaud, J. et al. (1995) J. Biol. Chem. 270, 7420-7426. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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