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Antigenic Specificity | TAK1 (C-term), 574-606 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 1.49 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This TAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 574-606 amino acids from the C-terminal region of human TAK1. TAK1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. |
Immunogen | n/a |
Other Names | [Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K7; TAK1] |
Gene, Accession # | [MAP3K7], Gene ID: 6885, NCBI: NP_003179.1, UniProt: O43318 |
Catalog # | MBS9204051 |
Price | $165, $370 |
Order / More Info | TAK1 (C-term), 574-606 Antibody from MYBIOSOURCE INC. |
Product Specific References | Cheung, P.C., et al., EMBO J. 22(21):5793-5805 (2003). Sakurai, H., et al., J. Biol. Chem. 278(38):36916-36923 (2003). Ono, K., et al., Biochem. Biophys. Res. Commun. 307(2):332-337 (2003). Edlund, S., et al., Mol. Biol. Cell 14(2):529-544 (2003). Takaesu, G., et al., J. Mol. Biol. 326(1):105-115 (2003). |